| 31‑Oct‑2022 | Paris Masters | Hard | R16 | 188 | 8 | (8)Felix Auger Aliassime [CAN] d. (WC)Simon | 6-1 6-3 | (ch) | 0.65 | 3.6% | 0.0% | 56.4% | 61.3% | 37.5% | 3/7 | 1:33 |
| 31‑Oct‑2022 | Paris Masters | Hard | R32 | 188 | 11 | (WC)Simon d. (9)Taylor Fritz [USA] | 7-5 5-7 6-4 | (ch) | 1.08 | 3.6% | 1.8% | 59.8% | 70.1% | 55.6% | 6/9 | 3:06 |
| 31‑Oct‑2022 | Paris Masters | Hard | R64 | 188 | 48 | (WC)Simon d. Andy Murray [GBR] | 4-6 7-5 6-3 | (ch) | 1.16 | 3.2% | 3.2% | 55.8% | 67.9% | 52.4% | 6/10 | 2:50 |
| 24‑Oct‑2022 | Brest CH | Hard | QF | 195 | 110 | (3)Gregoire Barrere [FRA] d. Simon | W/O | | | | | | | | | |
| 24‑Oct‑2022 | Brest CH | Hard | R16 | 195 | 141 | Simon d. (6)Matteo Arnaldi [ITA] | 6-2 6-2 | | 1.58 | 1.7% | 0.0% | 69.5% | 75.6% | 50.0% | 4/4 | 1:22 |
| 24‑Oct‑2022 | Brest CH | Hard | R32 | 195 | 198 | Simon d. Laurent Lokoli [FRA] | 6-2 6-4 | (ch) | 1.72 | 5.9% | 0.0% | 70.6% | 72.2% | 66.7% | 1/2 | 1:43 |
| 3‑Oct‑2022 | Mouilleron Le Captif CH | Hard | R32 | 169 | 338 | (LL)Kenny De Schepper [FRA] d. Simon | 7-6(5) 6-6 RET | | 0.98 | 2.6% | 0.0% | 55.8% | 74.4% | 61.8% | 2/3 | 1:55 |
| 19‑Sep‑2022 | Metz | Hard | R16 | 175 | 65 | Lorenzo Sonego [ITA] d. (WC)Simon | 7-6(2) 6-4 | | 0.66 | 2.4% | 2.4% | 54.2% | 64.4% | 52.6% | 5/7 | 2:08 |
| 19‑Sep‑2022 | Metz | Hard | R32 | 175 | 62 | (WC)Simon d. David Goffin [BEL] | 6-3 6-3 | (ch) | 1.51 | 2.0% | 4.1% | 63.3% | 74.2% | 61.1% | 1/2 | 1:33 |
| 12‑Sep‑2022 | Rennes CH | Hard | R32 | 175 | 216 | (WC)Dominic Thiem [AUT] d. Simon | 4-6 6-3 6-2 | (ch) | 0.76 | 6.3% | 2.5% | 60.0% | 70.8% | 40.6% | 2/6 | 2:29 |
| 29‑Aug‑2022 | US Open | Hard | Q2 | 182 | 187 | Matteo Arnaldi [ITA] d. Simon | 6-1 3-6 6-4 | | 0.83 | 0.0% | 4.7% | 79.2% | 50.0% | 36.4% | 10/17 | 2:23 |
| 29‑Aug‑2022 | US Open | Hard | Q1 | 182 | 155 | Simon d. Michael Mmoh [USA] | 2-6 7-5 6-1 | | 1.11 | 6.7% | 1.1% | 60.7% | 57.4% | 57.1% | 3/8 | 2:31 |
| 15‑Aug‑2022 | Vancouver CH | Hard | QF | 193 | 145 | Vasek Pospisil [CAN] d. (Alt)Simon | 6-1 7-5 | | 0.87 | 3.1% | 3.1% | 62.5% | 55.0% | 37.5% | 6/12 | 2:00 |
| 15‑Aug‑2022 | Vancouver CH | Hard | R16 | 193 | 67 | (Alt)Simon d. (2)Jiri Vesely [CZE] | 2-6 6-3 7-6(0) | | 0.91 | 4.0% | 9.1% | 56.6% | 69.6% | 53.5% | 2/5 | 2:20 |
| 15‑Aug‑2022 | Vancouver CH | Hard | R32 | 193 | 340 | (Alt)Simon d. (Q)Ulises Blanch [USA] | 6-4 7-6(3) | | 1.19 | 3.0% | 4.5% | 68.7% | 69.6% | 47.6% | 1/4 | 2:00 |
| 25‑Jul‑2022 | Umag | Clay | Q1 | 182 | 168 | (8)Giulio Zeppieri [ITA] d. Simon | 4-6 6-3 7-5 | | 0.92 | 2.2% | 2.2% | 66.3% | 63.9% | 45.2% | 7/12 | 2:45 |
| 18‑Jul‑2022 | Trieste CH | Clay | R32 | 175 | 156 | Geoffrey Blancaneaux [FRA] d. Simon | 6-3 7-6(4) | | 0.95 | 0.0% | 3.9% | 72.4% | 56.4% | 38.1% | 7/12 | 2:44 |
| 11‑Jul‑2022 | Verona CH | Clay | R32 | 177 | 337 | Francesco Maestrelli [ITA] d. Simon | 6-3 6-2 | | 0.84 | 0.0% | 0.0% | 52.9% | 51.9% | 45.8% | 4/9 | 1:42 |
| 4‑Jul‑2022 | Salzburg CH | Clay | R32 | 170 | 439 | (WC)Lukas Neumayer [AUT] d. Simon | 6-2 6-4 | | 0.53 | 1.9% | 3.8% | 43.4% | 65.2% | 43.3% | 2/6 | 1:23 |
| 27‑Jun‑2022 | Wimbledon | Grass | Q1 | 170 | 245 | Duje Ajdukovic [CRO] d. (12)Simon | 6-2 6-3 | | 0.51 | 0.0% | 1.5% | 82.1% | 45.5% | 58.3% | 9/14 | 1:06 |
| 13‑Jun‑2022 | Ilkley CH | Grass | Q1 | 126 | 431 | (WC)Charles Broom [GBR] d. (2)Simon | 6-4 6-1 | | 0.51 | 1.5% | 2.9% | 70.6% | 54.2% | 55.0% | 4/8 | 1:05 |
| 6‑Jun‑2022 | s Hertogenbosch | Grass | R16 | 134 | 2 | (1)Daniil Medvedev [RUS] d. (Q)Simon | 7-5 6-4 | (ch) | 0.78 | 0.0% | 2.6% | 65.8% | 62.0% | 57.7% | 5/8 | 1:52 |
| 6‑Jun‑2022 | s Hertogenbosch | Grass | R32 | 134 | 71 | (Q)Simon d. James Duckworth [AUS] | 6-4 7-6(9) | | 1.51 | 7.7% | 2.6% | 67.9% | 77.4% | 64.0% | 5/6 | |
| 6‑Jun‑2022 | s Hertogenbosch | Grass | Q2 | 134 | 299 | (4)Simon d. Julian Lenz [GER] | 4-6 6-3 6-2 | | 1.31 | 10.8% | 5.4% | 65.6% | 77.0% | 40.6% | 4/6 | 2:26 |
| 6‑Jun‑2022 | s Hertogenbosch | Grass | Q1 | 134 | 323 | (4)Simon d. Goncalo Oliveira [POR] | 6-3 3-6 6-2 | | 1.31 | 6.4% | 6.4% | 67.9% | 77.4% | 44.0% | 5/7 | 1:48 |
| 23‑May‑2022 | Roland Garros | Clay | R32 | 158 | 23 | (20)Marin Cilic [CRO] d. Simon | 6-0 6-3 6-2 | (ch) | 0.59 | 1.4% | 1.4% | 68.9% | 39.2% | 43.5% | 5/13 | |
| 23‑May‑2022 | Roland Garros | Clay | R64 | 158 | 92 | Simon d. Steve Johnson [USA] | 7-5 6-1 7-6(6) | (ch) | 1.34 | 4.9% | 2.0% | 72.5% | 67.6% | 53.6% | 3/7 | |
| 23‑May‑2022 | Roland Garros | Clay | R128 | 158 | 18 | (WC)Simon d. (16)Pablo Carreno Busta [ESP] | 6-4 6-4 4-6 1-6 6-4 | (ch) | 1.00 | 2.1% | 3.5% | 56.6% | 61.7% | 48.4% | 10/19 | |
| 16‑May‑2022 | Lyon | Clay | R32 | 159 | 24 | (5)Karen Khachanov [RUS] d. (Q)Simon | 6-1 6-4 | | 0.51 | 4.5% | 3.0% | 59.1% | 66.7% | 33.3% | 2/5 | 1:32 |
| 16‑May‑2022 | Lyon | Clay | Q2 | 159 | 269 | (6)Simon d. Nerman Fatic [BIH] | 6-0 7-5 | | 1.48 | 1.6% | 3.3% | 77.0% | 68.1% | 57.1% | 7/8 | 1:39 |
| 16‑May‑2022 | Lyon | Clay | Q1 | 159 | 341 | (6)Simon d. Matthias Bachinger [GER] | 6-2 6-4 | | 1.24 | 1.6% | 1.6% | 66.1% | 68.3% | 52.4% | 8/9 | 1:16 |
| 9‑May‑2022 | Heilbronn CH | Clay | R32 | 160 | 314 | (Q)Oleksii Krutykh [UKR] d. Simon | 6-2 6-1 | | 0.44 | 3.2% | 4.8% | 38.7% | 58.3% | 39.5% | 9/14 | 1:18 |
| 25‑Apr‑2022 | Rome CH | Clay | R32 | 158 | 178 | Gian Marco Moroni [ITA] d. (8)Simon | 6-1 6-4 | | 0.63 | 0.0% | 5.8% | 63.5% | 48.5% | 31.6% | 2/7 | 1:37 |
| 18‑Apr‑2022 | Belgrade | Clay | Q1 | 159 | 161 | (6)Damir Dzumhur [BIH] d. Simon | 3-6 7-5 6-2 | | 0.86 | 1.0% | 5.2% | 70.1% | 50.0% | 41.4% | 8/15 | 2:24 |
| 11‑Apr‑2022 | Barletta CH | Clay | R32 | 154 | 244 | Marius Copil [ROU] d. (1)Simon | 6-2 4-6 6-4 | | 0.83 | 4.8% | 4.8% | 67.9% | 61.4% | 44.4% | 5/10 | 2:14 |
| 28‑Mar‑2022 | Saint-Brieuc CH | Hard | R32 | 139 | 278 | Evgeny Karlovskiy [RUS] d. (3)Simon | 6-7(5) 7-6(5) 7-5 | | 0.99 | 6.8% | 4.2% | 64.4% | 78.9% | 47.6% | 10/12 | 3:04 |
| 21‑Mar‑2022 | Miami Masters | Hard | R128 | 139 | 146 | (WC)Jack Draper [GBR] d. (PR)Simon | 7-5 6-1 | | 0.71 | 3.1% | 10.8% | 52.3% | 61.8% | 38.7% | 3/8 | 1:48 |
| 14‑Mar‑2022 | Phoenix CH | Hard | R32 | 139 | 157 | (WC)Christopher Eubanks [USA] d. (Q)Simon | 6-4 7-5 | | 0.81 | 5.6% | 9.7% | 54.2% | 59.0% | 39.4% | 5/10 | 1:24 |
| 14‑Mar‑2022 | Phoenix CH | Hard | Q2 | 139 | 158 | (2)Simon d. (7)Tomas Machac [CZE] | 7-5 6-1 | | 1.29 | 3.0% | 4.5% | 67.2% | 68.9% | 68.2% | 3/3 | 1:26 |
| 14‑Mar‑2022 | Phoenix CH | Hard | Q1 | 139 | | (2)Simon d. (WC)Murphy Cassone [USA] | 6-3 6-1 | | 1.97 | 2.2% | 4.4% | 73.3% | 81.8% | 58.3% | 0/0 | 1:03 |
| 21‑Feb‑2022 | Pau CH | Hard | QF | 148 | 229 | Manuel Guinard [FRA] d. (6)Simon | 6-2 6-2 | | 0.37 | 2.0% | 4.1% | 49.0% | 66.7% | 32.0% | 2/6 | 1:03 |
| 21‑Feb‑2022 | Pau CH | Hard | R16 | 148 | 295 | (6)Simon d. Ruben Bemelmans [BEL] | 7-6(3) 7-5 | | 1.23 | 3.8% | 7.6% | 63.3% | 76.0% | 48.3% | 2/4 | 2:08 |
| 21‑Feb‑2022 | Pau CH | Hard | R32 | 148 | 306 | (6)Simon d. (Q)Emilio Nava [USA] | 6-4 7-6(2) | | 1.30 | 4.2% | 1.4% | 66.2% | 78.7% | 66.7% | 1/1 | 1:38 |
| 14‑Feb‑2022 | Marseille | Hard | R32 | 132 | 243 | (WC)Jo Wilfried Tsonga [FRA] d. (WC)Simon | 6-2 6-4 | | 0.59 | 4.1% | 2.0% | 63.3% | 67.7% | 44.4% | 2/5 | 1:10 |
| 7‑Feb‑2022 | Cherbourg CH | Hard | R16 | 124 | 261 | Ernests Gulbis [LAT] d. (5)Simon | 6-3 2-6 6-3 | | 0.97 | 7.1% | 4.7% | 62.4% | 73.6% | 40.6% | 6/9 | 2:06 |
| 7‑Feb‑2022 | Cherbourg CH | Hard | R32 | 124 | 194 | (5)Simon d. Marc Andrea Huesler [SUI] | 4-6 7-6(5) 6-4 | | 1.19 | 8.4% | 3.2% | 58.9% | 82.1% | 46.2% | 1/5 | 2:22 |
| 31‑Jan‑2022 | Montpellier | Hard | R16 | 130 | 19 | (2)Roberto Bautista Agut [ESP] d. (Q)Simon | 6-4 3-2 RET | | 0.77 | 6.8% | 0.0% | 55.9% | 69.7% | 30.8% | 6/9 | 1:22 |
| 31‑Jan‑2022 | Montpellier | Hard | R32 | 130 | 156 | (Q)Simon d. (WC)Lucas Pouille [FRA] | 7-6(4) 5-7 6-4 | | 1.10 | 5.0% | 1.7% | 69.2% | 67.5% | 54.1% | 6/9 | 2:54 |
| 31‑Jan‑2022 | Montpellier | Hard | Q2 | 130 | 211 | (4)Simon d. (Alt)Antoine Hoang [FRA] | 6-4 7-5 | | 1.23 | 6.2% | 3.1% | 64.6% | 61.9% | 60.9% | 3/6 | 1:45 |
| 31‑Jan‑2022 | Montpellier | Hard | Q1 | 130 | 191 | (4)Simon d. Marc Andrea Huesler [SUI] | 7-6(7) 7-6(7) | | 0.96 | 15.1% | 7.5% | 61.3% | 68.4% | 36.1% | 2/6 | 2:01 |
| 24‑Jan‑2022 | Quimper CH | Hard | R32 | 123 | 171 | Kacper Zuk [POL] d. (4)Simon | 7-6(5) 4-6 6-3 | | 1.20 | 8.2% | 4.1% | 57.7% | 80.4% | 48.8% | 6/8 | 2:39 |
| 17‑Jan‑2022 | Australian Open | Hard | Q1 | 123 | 1768 | (WC)Edward Winter [AUS] d. (4)Simon | 6-3 1-6 6-3 | | 1.00 | 2.5% | 3.8% | 72.5% | 58.6% | 54.5% | 3/7 | 2:15 |
| 3‑Jan‑2022 | Traralgon CH | Hard | QF | 122 | 226 | (12)Jesper De Jong [NED] d. (1)Simon | 6-4 6-1 | | 0.67 | 1.9% | 5.6% | 59.3% | 59.4% | 54.5% | 3/6 | 1:25 |
| 3‑Jan‑2022 | Traralgon CH | Hard | R16 | 122 | 235 | (1)Simon d. (15)Geoffrey Blancaneaux [FRA] | 6-0 2-1 RET | | 2.43 | 4.8% | 4.8% | 47.6% | 80.0% | 72.7% | 0/0 | 0:52 |
| 3‑Jan‑2022 | Traralgon CH | Hard | R32 | 122 | 261 | (1)Simon d. Tim Van Rijthoven [NED] | 6-0 6-2 | | 2.63 | 5.4% | 0.0% | 73.0% | 77.8% | 70.0% | 0/0 | 1:12 |
