| 3‑Feb‑2024 | Davis Cup QLS R1: CHI vs PER | Hard | RR | 87 | 20 | Nicolas Jarry [CHI] d. Varillas | 6-2 6-4 | | 0.22 | 4.8% | 3.6% | 64.3% | 66.7% | 33.3% | 11/14 | 1:36 |
| 20‑Sep‑2023 | Chengdu | Hard | R16 | 70 | 20 | (3)Grigor Dimitrov [BUL] d. Varillas | 6-3 6-4 | | 0.71 | 3.8% | 1.9% | 40.4% | 71.4% | 32.3% | 2/7 | 1:25 |
| 28‑Aug‑2023 | US Open | Hard | R64 | 74 | 9 | (9)Taylor Fritz [USA] d. Varillas | 6-1 6-2 6-2 | | 0.67 | 1.7% | 3.4% | 57.6% | 61.8% | 40.0% | 1/7 | 1:41 |
| 3‑Jul‑2023 | Wimbledon | Grass | R128 | 63 | 16 | (14)Lorenzo Musetti [ITA] d. Varillas | 6-3 6-1 7-5 | | 0.67 | 4.8% | 3.6% | 61.9% | 61.5% | 46.9% | 6/12 | 2:02 |
| 29‑May‑2023 | Roland Garros | Clay | R16 | 94 | 3 | (3)Novak Djokovic [SRB] d. Varillas | 6-3 6-2 6-2 | (ch) | 0.51 | 4.2% | 0.0% | 65.3% | 53.2% | 44.0% | 6/12 | 1:57 |
| 29‑May‑2023 | Roland Garros | Clay | R32 | 94 | 14 | Varillas d. (13)Hubert Hurkacz [POL] | 3-6 6-3 7-6(3) 4-6 6-2 | (ch) | 1.20 | 4.8% | 0.7% | 59.6% | 70.1% | 69.5% | 4/7 | 3:52 |
| 17‑Apr‑2023 | Banja Luka | Clay | R16 | 92 | 6 | (2)Andrey Rublev [RUS] d. Varillas | 6-2 6-2 | | 0.51 | 3.8% | 5.8% | 63.5% | 54.5% | 31.6% | 3/7 | 1:09 |
| 13‑Feb‑2023 | Buenos Aires | Clay | SF | 101 | 12 | (2)Cameron Norrie [GBR] d. (Q)Varillas | 7-6(5) 6-4 | | 0.74 | 6.4% | 1.3% | 70.5% | 70.9% | 43.5% | 6/8 | 1:53 |
| 13‑Feb‑2023 | Buenos Aires | Clay | QF | 101 | 20 | (Q)Varillas d. (3)Lorenzo Musetti [ITA] | 6-4 6-4 | | 1.25 | 3.0% | 0.0% | 63.6% | 73.8% | 45.8% | 3/5 | 1:46 |
| 16‑Jan‑2023 | Australian Open | Hard | R128 | 103 | 13 | (12)Alexander Zverev [GER] d. (LL)Varillas | 4-6 6-1 5-7 7-6(3) 6-4 | (ch) | 0.72 | 8.4% | 0.0% | 61.2% | 69.7% | 49.3% | 13/18 | 4:06 |
| 18‑Jul‑2022 | Gstaad | Clay | R16 | 115 | 19 | (Q)Varillas d. (3)Roberto Bautista Agut [ESP] | 7-6(3) 7-5 | | 1.12 | 6.0% | 4.8% | 48.2% | 67.5% | 60.5% | 2/4 | 2:29 |
| 23‑May‑2022 | Roland Garros | Clay | R128 | 122 | 9 | (9)Felix Auger Aliassime [CAN] d. (Q)Varillas | 2-6 2-6 6-1 6-3 6-3 | | 0.88 | 1.8% | 0.9% | 63.7% | 62.5% | 61.0% | 3/8 | |
| 24‑Jul‑2021 | Tokyo Olympics | Hard | R64 | 122 | 13 | (8)Diego Schwartzman [ARG] d. Varillas | 7-5 6-4 | | | | | | | | | |